Development of TransEthosomes Loaded with Fruit Extract from Carissa Carandas L. As a Brightening and Anti-Aging Cosmeceutical Ingredient

Transethosomes for Enhanced Skin Penetration and Anti-Aging Benefits

Transethosomes are an innovative cosmeceutical ingredient designed to improve skin penetration and reduce toxicity. They are particularly beneficial in delivering active compounds such as Carissa carandas L. Extract (ECE), which has shown:

Tyrosinase Inhibition: Helps in skin whitening by reducing melanin production.

Enhanced Fibroblast Proliferation: Promotes healthier, youthful skin by stimulating cell growth.

Collagen Type I Formation: Supports skin structure and elasticity, aiding in anti-aging effects.

However, the stratum corneum (outer skin layer) limits direct absorption. To overcome this, transethosomes—composed of phospholipids, ethanol, and surfactants—were formulated using sonication, significantly improving ECE’s skin penetration while maintaining low cytotoxicity in normal human dermal fibroblast cells.

Active compounds in ECE, like Malic acid, Rutin, Quercetin, and Ursolic acid, enhance the extract’s antioxidant, anti-inflammatory, and skin-rejuvenating properties.

These ECE-loaded transethosomes present strong potential for anti-aging and skin-whitening products, offering enhanced delivery of active ingredients to deeper layers of the skin for better results.

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Source:  https://www.mdpi.com/2079-9284/11/6/199