Prostaglandin Analogues in Cosmetics: Literature Review, Market Survey, Analytical Method Development and Testing

The document provides a comprehensive exploration of the identification, development, and testing of analytical methods for detecting prostaglandin analogues in cosmetic products, particularly in eyelash growth formulations. It outlines the research objectives, literature review, analytical approaches, and challenges in this specialized area of cosmetic analysis.

Key Highlights:

• Research Focus:
  • Identification and quantification of prostaglandin analogues used in cosmetic products for their lash-enhancing effects.
• Literature Review:
  • Leveraging scientific databases like Google Scholar and ScienceDirect to gather studies and existing data on prostaglandin analogues in cosmetics and medicines.
• Analytical Methods:
  • Techniques used for detecting and measuring prostaglandin analogues include:
    • Reverse-phase liquid chromatography (RP-LC) with UV-vis detectors.
    • Mass spectrometry (MS) methods for high sensitivity and accuracy.
• Validation methods such as QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) and RP-HPLC-MS/MS are employed for precise measurement.

• Challenges in Cosmetic Analysis:
  • Variety of analogues: The presence of different prostaglandin analogues complicates detection and differentiation.
  • Interferences: Ingredients in cosmetics can interfere with the detection process, impacting the accuracy of results.
  • Validation and Calibration: Ensuring analytical methods are robust, reproducible, and reliable for commercial product analysis.
• Applications:
  • These methods are crucial for ensuring regulatory compliance, safety, and transparency in cosmetic products containing active prostaglandin analogues.

This study serves as a guideline for researchers and regulatory bodies to improve analytical methodologies and address challenges associated with detecting biologically active compounds in cosmetics.

Region: United Kingdom
Source: https://assets.publishing.service.gov.uk/media/67472647886c31e352d8d0b4/prostaglandin-analogues-in-cosmetics.pdf